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Complementary Positron Emission Tomographic Studies of the Striatal Dopaminergic System in Parkinson's Disease Arch Neurol 52:1183-1190, Antonini,A.,et al, 1995 See this aricle in Pubmed Article Abstract Our results show that FDOPA,RACLO,and FDG PET measurements provide complementary information to characterize metabolic and receptor changes in the stiatum of PD with different degrees of motor disability.The FDOPA uptake reflects the best motor-related pathologic features,as indicated by the significant correlation between Ki values and clinical scores.the significant association between RACLO and FDOPA in the putamen suggests that D2 dopamine receptor changes are related to the reduction of presynaptic dopaminergic nerve terminals.Putamen FDG increaSe is probably the result of more complex feedback mechanisms that are primarily induced by striatal dopamine deficiency,

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